Quasideterministic generation of maximally entangled states of two mesoscopic atomic ensembles by adiabatic quantum feedback

We introduce an efficient, quasideterministic scheme to generate maximally entangled states of two atomic ensembles. The scheme is based on quantum nondemolition measurements of total atomic populations and on adiabatic quantum feedback conditioned by the measurements outputs. The high efficiency of the scheme is tested and confirmed numerically for ideal photodetection as well as in the presence of losses.Comment: 7 pages, 6 figures, title changed, revised version published on Phys. Rev

Global gyrokinetic simulations of ITG turbulence in the configuration space of the Wendelstein 7-X stellarator

We study the effect of turbulent transport in different magnetic configurations of the Weldenstein 7-X stellarator. In particular, we performed direct numerical simulations with the global gyrokinetic code GENE-3D, modeling the behavior of Ion Temperature Gradient turbulence in the Standard, High-Mirror, and Low-Mirror configurations of W7-X. We found that the Low-Mirror configuration produces more transport than both the High-Mirror and the Standard configurations. By comparison with radially local simulations, we have demonstrated the importance of performing global nonlinear simulations to predict the turbulent fluxes quantitatively

Corrigendum: Electromagnetic turbulence suppression by energetic particle driven modes (2019 Nucl. Fusion 59 124001), Nuclear Fusion 60, 089501 (2020)

In recent years, a strong reduction of plasma turbulence in the presence of energetic particles has been reported in a number of magnetic confinement experiments and corresponding gyrokinetic simulations. While highly relevant to performance predictions for burning plasmas, an explanation for this primarily nonlinear effect has remained elusive so far. A thorough analysis finds that linearly marginally stable energetic particle driven modes are excited nonlinearly, depleting the energy content of the turbulence and acting as an additional catalyst for energy transfer to zonal modes (the dominant turbulence saturation channel). Respective signatures are found in a number of simulations for different JET and ASDEX Upgrade discharges with reduced transport levels attributed to energetic ion effects

Atm reactivation reverses ataxia telangiectasia phenotypes in vivo

Hereditary deficiencies in DNA damage signaling are invariably associated with cancer predisposition, immunodeficiency, radiation sensitivity, gonadal abnormalities, premature aging, and tissue degeneration. ATM kinase has been established as a central player in DNA double-strand break repair and its deficiency causes ataxia telangiectasia, a rare, multi-system disease with no cure. So ATM represents a highly attractive target for the development of novel types of gene therapy or transplantation strategies. Atm tamoxifen-inducible mouse models were generated to explore whether Atm reconstitution is able to restore Atm function in an Atm-deficient background. Body weight, immunodeficiency, spermatogenesis, and radioresistance were recovered in transgenic mice within 1 month from Atm induction. Notably, life span was doubled after Atm restoration, mice were protected from thymoma and no cerebellar defects were observed. Atm signaling was functional after DNA damage in vivo and in vitro. In summary, we propose a new Atm mouse model to investigate novel therapeutic strategies for ATM activation in ataxia telangiectasia disease

A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11

Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes. Haploidization is achieved via two successive rounds of chromosome segregation, meiosis I and II. In mammals, during prophase of meiosis I, homologous chromosomes align and synapse through a recombination-mediated mechanism initiated by the introduction of DNA double-strand breaks (DSBs) by the SPO11 protein. In male mice, if SPO11 expression and DSB number are reduced below heterozygosity levels, chromosome synapsis is delayed, chromosome tangles form at pachynema, and defective cells are eliminated by apoptosis at epithelial stage IV at a spermatogenesis-specific endpoint. Whether DSB levels produced in Spo11 (+/-) spermatocytes represent, or approximate, the threshold level required to guarantee successful homologous chromosome pairing is unknown. Using a mouse model that expresses Spo11 from a bacterial artificial chromosome, within a Spo11 (-/-) background, we demonstrate that when SPO11 expression is reduced and DSBs at zygonema are decreased (approximately 40 % below wild-type level), meiotic chromosome pairing is normal. Conversely, DMC1 foci number is increased at pachynema, suggesting that under these experimental conditions, DSBs are likely made with delayed kinetics at zygonema. In addition, we provide evidences that when zygotene-like cells receive enough DSBs before chromosome tangles develop, chromosome synapsis can be completed in most cells, preventing their apoptotic elimination

Assessing global ion thermal confinement in critical-gradient-optimized stellarators

We investigate the confinement properties of two recently devised quasi-helically symmetric stellarator configurations, HSK and QSTK. Both have been optimized for large critical gradients of the ion temperature gradient mode, which is an important driver of turbulent transport in magnetic confinement fusion devices. To predict the resulting core plasma profiles, we utilize an advanced theoretical framework based on the gyrokinetic codes GENE and GENE-3D, coupled to the transport code TANGO. Compared to the HSX stellarator, both HSK and QSTK achieve significantly higher core-to-edge temperature ratios, partly thanks to their smaller aspect ratios, with the other part due to more detailed shaping of the magnetic geometry achieved during optimization. The computed confinement time, however, is less sensitive to core temperature than edge temperature, simply due to the disproportionate influence the edge has on stored plasma energy. We therefore emphasize the possible benefits of further optimizing turbulence in the outer core region, and the need to include accurate modelling of confinement in the edge region in order to assess overall plasma performance of turbulence optimized stellarators